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合作与联系

合作与联系

QFR®
定量血流分数检测仪

产品介绍

中国原创自研的冠脉功能学评估技术，仅需单幅/双幅造影，无需压力导丝与充血药物，快速完成QFR计算，评估心肌缺血情况。该技术斩获国家科技进步二等奖。

功能介绍

*QFR和μQFR在非大陆地区也称μFR

临床价值

  • 01

    精准评估缺血病变，指导治疗决策

  • 02

    复杂病变精准评估，优化手术策略

  • 03

    术前虚拟规划，术后精准验证疗效

  • 04

    同步评估微循环，无需额外操作

  • 05

    造影评估斑块稳定性，预测远期风险

  • 06

    解剖+功能双维评估，一站式指导PCI

Angiography-derived fractional flow reserve versus coronary angiography to guide coronary artery bypass grafting in patients undergoing surgical valve procedures with concomitant coronary artery disea

Zhu Y, Cheng Z, Zhao Y, et al. Lancet. 2026;407:1161-1170. doi:10.1016/S0140-6736(25)02418-3

FAVOR IV-QVAS研究证实，瓣膜手术合并冠心病患者中，μQFR指导的CABG相比解剖学指导可降低围术期事件率，中位随访27个月不增加不良心血管事件

Complete Revascularization Guided by Functional Coronary Angiography in STEMI

Biscaglia S, Erriquez A, Colaiori I, et al. N Engl J Med. 2026. doi:10.1056/NEJMoa2605373

AIR-STEMI研究（1823例）证实，STEMI合并多支病变患者中，μQFR指导的完全血运重建可降低38%主要不良事件风险（8.9% vs 13.7%，P<0.001），同时减少对比剂肾病与大出血

Radial wall strain for residual risk stratification after percutaneous coronary intervention

Huang J, Tu S, Huang H, et al. EuroIntervention. 2026;22:e978-e989. doi:10.4244/EIJ-D-26-00126

TARGET All Comers研究显示，造影衍生RWS可独立预测PCI术后非靶血管长期不良事件（HR 4.82），对非靶血管血运重建预测准确性最高（AUC 0.92）

Prognostic Impact of Quantitative Flow Ratio-Derived Physiology for Intermediate Non-Infarct-Related Artery in Acute Myocardial Infarction

Tsunamoto H, Otake H, et al. Heart Vessels. 2026. doi:10.1007/s00380-025-02650-3

μQFR衍生生理学指标可识别AMI患者中度非梗死相关动脉的高危病变，指导治疗决策，改善远期预后

VERMONT μQFR: Diagnostic Accuracy of Murray Law-Based 2D-μQFR Compared to 3D-μQFR and vFFR

Akrawi D, Kadappu K, Xu J, et al. Catheter Cardiovasc Interv. 2026. doi:10.1002/ccd.70768

VERMONT研究证实2D-μQFR诊断准确性优异（AUC 0.95，敏感度93%，特异度92%），分析时间比有创FFR快15分钟，观察者间一致性良好

Angiography-derived fractional flow reserve versus intravascular ultrasound to guide percutaneous coronary intervention in patients with coronary artery disease (FLAVOUR II): a multicentre, randomised

Hu X, Zhang J, Yang S, et al. Lancet. 2025. doi:10.1016/S0140-6736(25)00504-5

FLAVOUR II研究证实，μQFR指导PCI在12个月临床结局方面不劣于IVUS指导，且支架植入更少，为中度狭窄患者提供了更经济的选择

Angiography-Derived Microcirculatory Resistance in Detecting Microvascular Obstruction and Predicting Heart Failure After STEMI

Lu G, et al. Circ Cardiovasc Imaging. 2025;18:e017506. doi:10.1161/CIRCIMAGING.124.017506

造影衍生AMR可检测STEMI术后微血管梗阻并预测心力衰竭发生，无需额外操作即可实现微循环功能评估

Prognostic Implications of Angiographically Derived Coronary Radial Wall Strain in Diabetic Patients and Non–Flow-Limiting Stenosis

Wang Z, Kedhi E, Liu X, et al. JACC Cardiovasc Interv. 2025;18(10):1232-1242. doi:10.1016/j.jcin.2025.02.009

COMBINE OCT-FFR研究显示，RWS可预测糖尿病非血流受限病变的不良事件（HR 2.70），独立于且增量于OCT易损斑块特征，实现造影评估斑块稳定性

Single-view angiographic microcirculatory resistance index after primary PCI: the EARLY-MYO-AMR study

Zhang Z, Ding S, Guo Q, et al. EuroIntervention. 2025;21:e1015-e1027. doi:10.4244/EIJ-D-24-00952

EARLY-MYO-AMR 研究证实，直接 PCI 后 AMR>26.6 可预测微循环障碍（AUC 0.721）并独立预测长期 MACE，为 STEMI 提供无导丝微循环评估工具

Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio: Post Hoc Analysis From FLAVOUR Trial

Ding D, Zhang J, Koo BK, Tu S, et al. JACC: Asia. 2025;1:59-70.

FLAVOUR试验事后分析显示术后μQFR具有独立预后价值，可优化PCI术后功能学评估和患者长期管理

Three-Year Clinical Impact of Murray Law-Based Quantitative Flow Ratio and OCT- or FFR-Guidance in Angiographically Intermediate Coronary Lesions

Aurigemma C, Ding D, Burzotta F, et al. Circ Cardiovasc Interv. 2024;17(5):e013191. doi:10.1161/CIRCINTERVENTIONS.123.013191

μQFR指导中度病变治疗的3年临床结局与OCT/FFR指导相当，可减少有创操作和医疗费用，适合常规临床应用

Prognostic Value of Murray Law-Based QFR (μQFR)-Guided Virtual PCI in Patients With Physiological Ischemia

Chen L, Tu S, Luo Y, et al. Circ Cardiovasc Interv. 2024;17(10):e014362. doi:10.1161/CIRCINTERVENTIONS.124.014362

μQFR虚拟PCI指导生理性缺血患者治疗可改善预后，实现术前精准规划和术后疗效验证，优化介入策略

Coronary Physiology Guidance vs Conventional Angiography for Optimization of Percutaneous Coronary Intervention: The AQVA-II Trial

Biscaglia S, Verardi FM, Erriquez A, et al. JACC Cardiovasc Interv. 2024;17(2):277-287. doi:10.1016/j.jcin.2023.10.032

AQVA-II 研究证实，CHIP 患者中生理学指导 PCI 术后 FFR>0.86 达标率显著高于常规造影（77% vs 54%，P<0.0001），且造影衍生 FFR 不劣于微导管 FFR

Left main bifurcation stenting: impact of residual ischaemia on cardiovascular mortality

Wang HY, Zhang R, Dou K, et al. Eur Heart J. 2023;44(41):4324-4336. doi:10.1093/eurheartj/ehad318

左主干分叉支架术后μQFR检测到残余缺血者占13.2%，其心血管死亡率显著升高，提示术后功能学评估可识别"解剖成功但功能未达标"的高危患者，指导术后优化

The Association Between Angiographically Derived Radial Wall Strain and the Risk of Acute Myocardial Infarction

Li C, Wang Z, Yang H, et al. JACC Cardiovasc Interv. 2023;16(9):1039-1049. doi:10.1016/j.jcin.2023.02.012

研究证实造影衍生RWS高应变模式与轻中度病变未来AMI风险增加相关（AUC 0.83），可基于常规造影识别易损斑块，预测远期事件风险

Radial wall strain: a novel angiographic measure of plaque composition and vulnerability

Hong H, Li C, Gutiérrez-Chico JL, et al. EuroIntervention. 2022;18:1001-1010.

造影衍生RWS可评估斑块组成和易损性，与OCT脂质斑块特征显著相关，实现无创斑块稳定性评估和风险分层

Radial wall strain assessment from AI-assisted angiography: feasibility and agreement with OCT as reference standard

Huang J, Tu S, Li C, et al. J Soc Cardiovasc Angiogr Interv. 2023;2:100570. doi:10.1016/j.jscai.2022.100570

AI辅助造影RWS评估可行，与OCT易损斑块特征一致性良好，可常规应用于临床，实现自动化斑块稳定性评估

Short-Term Risk Stratification of Non–Flow-Limiting Coronary Stenosis by Angiographically Derived Radial Wall Strain

Tu S, et al. J Am Coll Cardiol. 2023;81:756-767. doi:10.1016/j.jacc.2022.11.056

造影衍生RWS可对非血流受限狭窄进行短期风险分层，RWS≥13%识别易损斑块，预测远期事件风险，指导强化治疗（FAVOR III China RWS）

Two birds with one stone: integrated assessment of coronary physiology and plaque vulnerability from a single angiographic view- a case report

Fezzi S, et al. Eur Heart J Case Rep. 2023;7:ytad309. doi:10.1093/ehjcr/ytad309

单体位造影可同时评估μQFR功能学和RWS斑块易损性，实现一站式功能+结构双维评估，优化临床决策

Feasibility of Quantitative Flow Ratio Virtual Stenting for Guidance of Serial Coronary Lesions Intervention

Guan S, Gan Q, Han W, et al. J Am Heart Assoc. 2022. doi:10.1161/JAHA.122.025663

研究证实μQFR虚拟支架可在串联病变中精准识别主要血流受限病变，指导分期介入策略，与FFR高度相关（r=0.97），实现术前虚拟规划

Quantitative Flow Ratio Based on Murray Fractal Law: Accuracy of Single Versus Two Angiographic Views

Tu S, et al. J Soc Cardiovasc Angiogr Interv. 2022;1:100399. doi:10.1016/j.jscai.2022.100399

单体位μQFR与双体位μQFR诊断准确性相当，简化操作流程，提高临床应用效率，适合急诊和复杂病变场景

In Vivo Validation of a Novel Computational Approach to Assess Microcirculatory Resistance Based on a Single Angiographic View

Fan Y, Fezzi S, Sun P, et al. J Pers Med. 2022;12(11):1798. doi:10.3390/jpm12111798

单体位造影AMR与有创IMR相关性良好（r=0.83），诊断准确性AUC 0.94，实现无创微循环功能评估

Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: A novel method based on bifurcation fractal law

Tu S, Ding D, Chang Y, Li C, Wijns W, Xu B. Catheter Cardiovasc Interv. 2021;97:1040-1047. doi:10.1002/ccd.29592

基于Murray分形法则的单体位μQFR诊断准确性优异，可行性高，可识别血流动力学显著狭窄，无需压力导丝

Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial

Xu B, Tu S, Song L, et al. Lancet. 2021;398:2149-2159. doi:10.1016/S0140-6736(21)02248-0

FAVOR III China研究（3847例）证实μQFR指导PCI可显著降低1年主要不良事件风险35%，减少不必要支架植入，在合理控制医疗支出前提下减轻患者负担

Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis

Xu B, Tu S, Qiao S, et al. J Am Coll Cardiol. 2017;70(25):3077-3087. doi:10.1016/j.jacc.2017.10.035

FAVOR II China研究（308例）证实μQFR诊断准确性达92.4%，显著优于预设目标，验证了μQFR无需压力导丝和充血药物的临床可行性